Development of medical devices based on functionalized nanofibers for topical applications, skin coverings and regenerative surgery

The goal of the project was the preparation of functionalized nanosystems with controlled release of biologically active substances. The experimental work was focused on the optimization of the method for the preparation of microparticles for the treatment of connective tissue defects, the non-invasive treatment of skin tissue injuries and the characterization of the differentiation of mesenchymal stem cells in the developed nanostructures. Furthermore, polymer biomaterials were optimized, with use mainly as scaffolds for the proliferation and differentiation of mesenchymal stem cells for applications in regenerative medicine, which subsequently underwent in vitro testing successfully.