Development of second-generation smart nanofibers for medical applications and medical systems for targeted and controlled delivery of bioactive substances
Provider: MPO
This project was implemented in the category of collective research and is divided into three sub-projects, which are described in more detail below. The implementation phase of all sub-projects of this project started in July 2015 and was completed in July 2018. A number of small and medium-sized enterprises and research institutions participated in the implementation of the project. All the set objectives of the project were met in full.
Qualitative parameters of nanofibrous scaffolds for human, veterinary, food and special applications
As part of this research project, analytical testing of the nanomaterial preparation process is carried out in terms of unwanted residues in individual phases and in the final structure, including the content of functionalized additives (photocatalytic and magnetic). The goal is to optimize the production process in terms of quality and at the same time create reliable control procedures for evaluation. The output of the research will be indispensable qualitative data usable for legislative approval processes in the given application area, which will enable more effective commercialization of specific future developed products. Eligible expenses of the sub-project were supported from the Operational Program Entrepreneurship and Innovation for the Competitiveness of the Cooperation - Clusters call. So far, has mainly been carried out on refining methods and polymer analysis research. Suitable phthalocyanine derivatives, refining methodology and polymer modification procedures with these derivatives were investigated, and optimization of photoactively modified nanomaterial and tests of functionalized nanofabrics took place. In the second research area of this sub-project, the optimization of the preparation of magnetic liquids for incorporation into nanofibers and the modification of nanomaterials with suitable magnetic liquids and nanoparticles took place. The implemented activities take place in accordance with the project schedule.
Development of composite materials with an integrated nanofibrous layer and functionalized nanofibrous structures for industrial applications
The main goals of the research are the optimization of the AC preparation of nanofibers, including coaxial ones, the preparation of flat nanostructures and composite membranes with specific properties, as well as the functionalization of these nanostructures by incorporating granular materials. As part of the stages that have already paased off, there was mainly research of the mixing AC nanofibrous material with granules and research of the methodology of preparing linear and flat materials. Furthermore, a search for powder sorbents suitable for protective effectiveness was accomplished. The key parameters and properties of the composite functional membrane were also investigated, and the characterization of the prepared nanofibrous layers and their functionalization was carried out. During the course of the research, linear composite nanofibrous formations were further optimized in relation to their later processing into tissue or knitted form. The implemented activities took place in accordance with the project schedule.
Development of second-generation smart nanofibers for medical applications and medical systems for targeted and controlled delivery of bioactive substances
The goal of the sub-project is to develop functionalized nanofibrous structures for applications in the field of ultrasensitive biosensors for the contamination detection of gaseous and liquid surroundings with microparticles of biological and non-biological origin, as well as for applications in the field of foam carriers made of intercellular material designated for the regeneration of bone defects after tooth extraction, applications in the field food supplements with local and time-controlled release and skin coverings containing allogeneic extraembryonic stem cells.
The preparation and testing of a 3D carrier for cell culture was mainly accomplished, and nanostructured samples were prepared for the detection of microbial pollution. The preparation and testing of nanostructure-functionalized injectable systems using peptide gels, collagen and fibrin gel took place. Furthermore, suitable candidates for encapsulation and suitable polymers for them were selected. A suitable methodology for the isolation and cultivation of extraembryonic stem cells was investigated. The implemented activities took place in accordance with the time schedule.
